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Topotecan hydrochloride

detailed description:

C23H24ClN3O5                                  Mr457.9

CAS:119413-54-6

Chemical name:(4S)-10-[(dimethylamino) methyl]- 4-ethyl-4,9-dihydroxy-1H-pyrano

[3' ,4' :6,7]indolizino[1 ,2- b]quinoline-3,14(4H,12H)-dione hydrochloride

Standard:IP

【Characters 】 A light yellow to greenish yellow powder.

【Identification】 Infrared absorption spectrophotometry.

【Test】

pH:3.5-4.5

Specific opticalrotation:+30.0o-38.0o

Related substance(HPLC): Unspecified impurities: ≤0.15%; Total impurities: ≤1.0%.

Water ≤13%.

Heavy metals: ≤20ppm

Sulfated ash ≤0.1%.

【Assay】 According to the calculation of dry products, containing C23H24ClN3O5 should be 98.0%-102.0%.


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